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Gli inibitori dell’enzima beta-secretasi (iBACE) sono farmaci sperimentali anti-amiloide per il trattamento dell’Alzheimer. Scopri i risultati degli studi sui pazienti e le domande che li sollevano per la ricerca futura.
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View/Edit Human. View/Edit Mouse. Beta-secretase 1, also known as beta-site amyloid precursor protein cleaving enzyme 1, beta-site APP cleaving enzyme 1 ( BACE1 ), membrane-associated aspartic protease 2, memapsin-2, aspartyl protease 2, and ASP2, is an enzyme that in humans is encoded by the BACE1 gene. [5]
1 apr 2021 · BACE1 (beta-site amyloid precursor protein cleaving enzyme 1) was initially cloned and characterized in 1999. It is required for the generation of all monomeric forms of amyloid-β (Aβ), including Aβ 42, which aggregates into bioactive conformational species and likely initiates toxicity in Alzheimer’s disease (AD).
- Harald Hampel, Robert Vassar, Bart De Strooper, Bart De Strooper, Bart De Strooper, John Hardy, Mich...
- 10.1016/j.biopsych.2020.02.001
- 2021
- 2021/04/04
15 apr 2021 · Abstract. BACE1 (beta-site amyloid precursor protein cleaving enzyme 1) was initially cloned and characterized in 1999. It is required for the generation of all monomeric forms of amyloid-β (Aβ), including Aβ 42, which aggregates into bioactive conformational species and likely initiates toxicity in Alzheimer's disease (AD).
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4 feb 2022 · Summary. β‐site amyloid precursor protein cleaving enzyme‐1 (BACE1) research has historically focused on its actions as the β‐secretase responsible for the production of β‐amyloid beta, observed in Alzheimer's disease. Although the greatest expression of BACE1 is found in the brain, BACE1 mRNA and protein is also found in ...
