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The discovery of James P. Allison and coworkers, utilizing the role of CTLA-4 as an inhibitor of activation and developing antibodies to release the brake. The graph shows the effect of anti-CTLA-4 treatment in tumor-bearing mice compared to controls. The development of clinical immune checkpoint inhibitor therapy
Fundamental mechanisms of immune checkpoint blockade therapy. SC Wei, CR Duffy, JP Allison. Cancer discovery 8 (9), 1069-1086. , 2018. 2601. 2018. Depletion of carcinoma-associated fibroblasts and fibrosis induces immunosuppression and accelerates pancreas cancer with reduced survival. BC Özdemir, T Pentcheva-Hoang, JL Carstens, X Zheng, CC Wu
Interview with Medicine Laureate James P. Allison on 6 December 2018 during the Nobel Week in Stockholm, Sweden. Read the interview. James P. Allison answers the following questions (the links below lead to clip on YouTube): 00:06 What triggered your interest in researching a new cancer therapy?
Tasuku Honjo. Prize share: 1/2. The Nobel Prize in Physiology or Medicine 2018 was awarded jointly to James P. Allison and Tasuku Honjo "for their discovery of cancer therapy by inhibition of negative immune regulation". To cite this section. MLA style: The Nobel Prize in Physiology or Medicine 2018. NobelPrize.org. Nobel Prize Outreach AB 2024.
James P. Allison, PhD, is professor and chair of the department of Immunology and the executive director of the immunotherapy platform at The University of Texas MD Anderson Cancer Center, where he also holds the Vivian Smith Distinguished Chair in Immunology. Allison’s research focuses on understanding the mechanisms that govern T-cell responses and applying that basic … Continued
Immune Checkpoint Blockade in Cancer Therapy. James P. Allison delivered his Nobel Lecture on 7 December 2018 at Aula Medica, Karolinska Institutet in Stockholm. He was introduced by Professor Edvard Smith, member of the Nobel Committee for Physiology or Medicine. MLA style: James P. Allison – Nobel Lecture.
In 2013, James headed back to Ferrari, this time as Technical Director. After a fruitless year for the team in 2014, James’ influence was crucial as Sebastian Vettel claimed three wins the following year, when the Scuderia emerged as the closest challenger to the title-winning Mercedes team.
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