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James Edwin Darnell Jr. (born September 9, 1930, Columbus, Mississippi) is an American biologist who made significant contributions to RNA processing and cytokine signaling and is author of the cell biology textbook Molecular Cell Biology.
James E. Darnell Jr., M.D. Vincent Astor Professor Emeritus. Laboratory of Molecular Cell Biology. The Darnell laboratory studies how signals from the cell surface affect the transcription of genes in the nucleus.
Biography of James E. Darnell, Jr. from Concept 35: DNA responds to signals from outside the cell, DNA from the Beginning.
To his credit, Darnell presents microRNAs and RNA interference in the chronological order of their discovery (which many authors unknowingly reverse) and, more au courant, he managed to get in some key advances on long noncoding RNAs that were breaking just when the book was going to press.
- Thoru Pederson
- 2011
James E. Darnell was awarded the National Medal of Science for his seminal scientific discoveries related to gene expression in animal cells, including pathways of RNA processing and signal transduction from the cell surface to genes in the nucleus, and for his contributions as a scientific educator.
James E. Darnell's 179 research works with 33,802 citations and 31,835 reads, including: The JAK-STAT pathway at 30: Much learned, much more to do
Dr. Darnell discovered the first processing RNAs (rRNA and tRNA) and co-discovered polyA tails in virtually all mRNAs. His studies on long nuclear RNA molecules, especially those copied from adenovirus DNA, laid the groundwork for the discovery of splicing.
