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1. www.centroalzheimer.org › esiste-un-futuro-per-gli-inibitoriEsiste un futuro per gli inibitori BACE nel trattamento della...

   www.centroalzheimer.org › esiste-un-futuro-per-gli-inibitori

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   Gli inibitori dell’enzima beta-secretasi (iBACE) sono tra i farmaci sperimentali anti-amiloide studiati per il trattamento della malattia di Alzheimer (AD).

2. en.wikipedia.org › wiki › Beta-secretase_1Beta-secretase 1 - Wikipedia

   en.wikipedia.org › wiki › Beta-secretase_1

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   Role in Alzheimer's disease. BACE1 is the major beta secretase for the generation of amyloid-β peptides in the neurons. [ 9] Generation of the 40 or 42 amino acid -long amyloid-β peptides that aggregate in the brain of Alzheimer's patients requires two sequential cleavages of the amyloid precursor protein (APP).

3. www.tripadvisor.it › Restaurant_Review-g1016840-d4105560AGRITURISMO DA BACÈ, Castelnuovo Magra - Tripadvisor

   www.tripadvisor.it › Restaurant_Review-g1016840-d4105560

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   204 recensioni. #4 di 18 ristoranti a Castelnuovo Magra €€-€€€, Italiana, Ligure, Italiana (nord) Via Provasco 6, 19033 Castelnuovo Magra Italia. +39 333 314 8917 + Aggiungi sito web. Ora chiuso Vedi tutti gli orari. Migliora questo profilo.

   • 4/5 (204)
   • Telefono: +39 333 314 8917

   • Località: IT
   • Categoria: Restaurant

4. www.ncbi.nlm.nih.gov › pmc › articlesThe β-Secretase BACE1 in Alzheimer’s Disease - PMC

   www.ncbi.nlm.nih.gov › pmc › articles

   1 apr 2021 · BACE1 (beta-site amyloid precursor protein cleaving enzyme 1) was initially cloned and characterized in 1999. It is required for the generation of all monomeric forms of amyloid-β (Aβ), including Aβ 42, which aggregates into bioactive conformational species and likely initiates toxicity in Alzheimer’s disease (AD).

   • Autore: Harald Hampel, Robert Vassar, Bart De Strooper, Bart De Strooper, Bart De Strooper, John Hardy, Mich...
   • DOI: 10.1016/j.biopsych.2020.02.001

   • Publish Year: 2021
   • Pubblicato: 2021/04/04

5. www.alzheimer-riese.it › index › contributi-dal-mondoEnzima BACE1 può predire l'insorgenza dell'Alzheimer

   www.alzheimer-riese.it › index › contributi-dal-mondo

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   1 gen 2014 · L'enzima cruciale beta-secretasi1 (BACE1) è noto per essere presente in quantità elevata nel cervello con Alzheimer ad insorgenza sporadica (AD). Gli scienziati hanno ora trovato un aumento del livello di BACE1 nel cervello con decadimento cognitivo lieve (MCI), suggerendo che l'attività del BACE1 è importante per la conversione ...

6. pubmed.ncbi.nlm.nih.gov › 35119166BACE1: More than just a β-secretase - PubMed

   pubmed.ncbi.nlm.nih.gov › 35119166

   β-site amyloid precursor protein cleaving enzyme-1 (BACE1) research has historically focused on its actions as the β-secretase responsible for the production of β-amyloid beta, observed in Alzheimer's disease. Although the greatest expression of BACE1 is found in the brain, BACE1 mRNA and protein is ….

7. www.ncbi.nlm.nih.gov › pmc › articlesBACE1: A Key Regulator in Alzheimer’s Disease Progression and...

   www.ncbi.nlm.nih.gov › pmc › articles

   5 mag 2022 · BACE1 is a type 1 transmembrane aspartyl protease consisting of 501 amino acids mainly expressed in the neurons. The extraneuronal portion of APP is cleaved by BACE1 to generate a large soluble extracellular fragment sAPPβ and an intracellular C-terminal fragment (βCTF) which is called C99 (Fig. 1 ).