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UCSF Chimera is a program for the interactive visualization and analysis of molecular structures and related data, including density maps, trajectories, and sequence alignments. It is available free of charge for noncommercial use.
- Download
Download Chimera. Current Production Releases. See the...
- Tutorials
A set of tutorials is included in the Chimera User's Guide....
- ChimeraX Commercial Licensing
Please note that UCSF Chimera is legacy software, meaning...
- Previously Featured Citations
Norovirus MLKL-like protein initiates cell death to induce...
- Release Notes
Chimera Release Notes. All releases with the same version...
- Publications
RRDistMaps: a UCSF Chimera tool for viewing and comparing...
- Videos
UCSF Chimera Video Documentation. Tom Goddard, Andrew Ling...
- Citing Chimera
Ursula Pieper - Chimera web data in ModBase; Elana Erez,...
- Download
Download Chimera. Current Production Releases. See the release notes for a list of new features and other information. For more recent changes , use the snapshot and daily builds; they are less tested but usually reliable. 64-bit Releases: 32-bit releases are no longer supported. Daily Builds. New builds are made when the code changes.
Fusion proteins or chimeric (kī-ˈmir-ik) proteins (literally, made of parts from different sources) are proteins created through the joining of two or more genes that originally coded for separate proteins.
5 set 2022 · Proteolysis targeting chimeras (PROTACs) are dual-functional hybrid mols. that can selectively recruit an E3 ubiquitin ligase to a target protein to direct the protein into the ubiquitin-proteasome system (UPS), thereby selectively reducing the target protein level by the ubiquitin-proteasome pathway.
27 lug 2023 · Bispecific DbTACs (bis-DbTACs) with trivalent ligand assembly enable multi-target depletion while maintaining highly selective degradation of protein subtypes.
27 lug 2022 · Proteins are naturally formed by domains edging their functional and structural properties. A domain out of the context of an entire protein can retain its structure and to some extent also function on its own. These properties rationalize construction of artificial fusion multidomain proteins with unique combination of various functions.
Novel BET protein proteolysis targeting chimera (BET-PROTAC) exerts superior lethal activity than bromodomain inhibitor (BETi) against post-myeloproliferative neoplasm (MPN) secondary (s) AML cells.
