Risultati di ricerca
10 mag 2024 · Le ricerche di de Lange aiutano a capire come mantenere i telomeri sani per prevenire il cancro, offrendo nuove strade per trattamenti futuri. «Titia de Lange ha vinto il premio per aver scoperto ...
13 feb 2024 · 2024 - Titia de Lange 2023 - Tak W. Mak 2022 - Steven A. Rosenberg 2021 - Hans Clevers 2020 - John E. Dick 2019 - Alberto Mantovani 2018 - Tony Hunter 2017 - David M. Livingston 2016 - Joan Massagué 2015 - James P. Allison - NOBEL 2018 2014 - Elaine Fuchs 2013 - Peter A. Vogt 2012 - Robert A. Weinberg 2011 - Pier Paolo Pandolfi
23 nov 2018 · Abstract. For more than a decade, it has been known that mammalian cells use shelterin to protect chromosome ends. Much progress has been made on the mechanism by which shelterin prevents telomeres from inadvertently activating DNA damage signaling and double-strand break (DSB) repair pathways. Shelterin averts activation of three DNA damage ...
2001 First Paul Marks Prize for Cancer Research, Memorial Sloan-Kettering Cancer Center. 2000 Elected Member, Royal Dutch Academy of Sciences. 1985 PhD, University of Amsterdam. A leader in expanding our understanding of how a cell responds when its DNA is damaged, Dr. de Lange focuses her research on how telomeres protect chromosome ends and ...
30 apr 2024 · The ends of eukaryotic chromosomes carry specific elements, telomeres, that mediate both the replication and protection of the terminal DNA. My goal is to understand how telomeres work. Our biochemical and cell biological studies on mammalian cells have identified a protein complex, shelterin, that binds telomeres but not other DNA ends.
Titia de Lange. Titia de Lange has made fundamental discoveries about chromosome structure and DNA repair—work that has led her to conduct a series of investigations aimed at improving breast cancer diagnosis and therapy. Recently, for example, Dr. de Lange began a study of DCIS, an early-stage, noninvasive form of breast cancer for which ...
Current research support (PI de Lange): NIH RO1 AG16642; Mechanism of the telomeric proliferation limit. 4/1/99-8/31/20. NIH RO1 1R35CA210036; Genome instability in cancer: telomeres and DNA repair. 9/2/16- 8/31/23. Breast Cancer Research Foundation; Genome instability and the onset of breast cancer. 10/1/03 to 09/30/20.
