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24 mar 2022 · Abstract. The design of proteins that bind to a specific site on the surface of a target protein using no information other than the three-dimensional structure of the target remains a challenge 1 ...
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Upon graduation, David returned to central Missouri and began playing acoustic shows in various bars and wineries. He has been the lead vocalist of a few central Missouri bands and is currently the lead vocalist in The Dave Baker Band. David recently began a new journey into the Trop Rock genre. His debut album "A Saltwater Opus in D Major (and ...
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This prize celebrates the accomplishments of the extraordinarily talented graduate students, postdoctoral fellows and staff I have been most fortunate to work with at the University of Washington and the Institute for Protein Design, and more broadly the collaborative achievements of the RosettaCommons which now spans 80 institutions. It also ...
13 gen 2023 · The crystal structure of a designed protein-peptide complex is close to the design model, and NMR characterization reveals how the peptide binding cleft is protected in the apo state. We use the approach to design binders to segments of the amyloid forming proteins Transthyretin, Tau, Serum amyloid A1 and Aβ42.
In a new study in Science, we introduce an AI-assisted drug discovery approach and use it to generate over 14.9 million never-before-seen peptides with appealing pharmaceutical features, including molecules that inhibit key proteins linked to coronavirus infection and cancer in the lab. This research was led by Patrick Salveson, a recent ...
