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3 giorni fa · Oral administration (PO: per os – by mouth) is a route where a substance (e.g. tablet, syrup) is taken through the mouth to be absorbed from the stomach or intestine, enters the liver and the general circulation.
2 giorni fa · Oral administration of nanomotorized mitochondria not only significantly restored cardiac function in a rat model of IHD, but also maintained cardiac function at this level for 2 weeks after ...
14 ore fa · Currently, 72 approved drugs are available, with an additional 180 PKIs undergoing clinical trials. 2, 3 Consequently, these oral agents are now extensively used on a daily basis for various malignancies. 3 Despite their clinical benefits, the oral administration of many TKIs, especially in conventional immediate-release (IR) dosage forms, presents therapeutic challenges.
5 giorni fa · When a medicine is given orally, only part of the administered dose appears in the plasma. (Example: if 100 mg of a medicine are administered orally and 70 mg of this medicine are absorbed unchanged, the bioavailability is 0.7 or seventy percent).
5 giorni fa · Vaccines intended for oral administration need not be liquid, and as solids, they commonly are more stable and less prone to damage or spoilage by freezing in transport and storage. Such stability reduces the need for a " cold chain ": the resources required to keep vaccines within a restricted temperature range from the manufacturing stage to the point of administration, which, in turn, may ...
1 giorno fa · Effects of oral administration of a nonselective Trk inhibitor (GNF 5837) on bladder activity in a mouse model of PI induced by prostate epithelial cell-specific deletion of the Cdh1 gene. (A) Representative traces of CMG under an awake condition in Control, Untreated and Treated mice after 10 days of GNF 5837 or vehicle treatment.
5 giorni fa · Mobocertinib (TAK-788) is a first-in-class oral epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor that received accelerated approval for the treatment of patients with non-small cell lung cancer with EGFR exon 20 insertion mutations previously treated with platinum-based chemotherapy. This phase 1, 2-period, study was conducted to assess the absolute bioavailability of ...
