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3 giorni fa · Drug use contributes to 500,000 deaths worldwide, with opioid overdose resulting in approximately 115,000 of these deaths in 2018. [1] This is up from 18,000 deaths in 1990. [13] [14] In 2018, approximately 269 million people had engaged in drug usage at least once, 58 million of which used opioids. [1]
3 giorni fa · Fentanyl poses an exceptionally high overdose risk in humans, since the amount required to cause toxicity is unpredictable. In its pharmaceutical form, most overdose deaths attributed solely to fentanyl occur at serum concentrations at a mean of 0.025 μg/mL, with a range 0.005–0.027 μg/mL.
1 giorno fa · Between 2000 and 2014 there was an "alarming increase in heroin use across the country and an epidemic of drug overdose deaths". [237] [211] [238] As a result, health care organizations and public health groups, such as Physicians for Responsible Opioid Prescribing, have called for decreases in the prescription of opioids. [237]
4 giorni fa · In the United Kingdom, LSD is a Class A drug under the Misuse of Drugs Act 1971, making unauthorized possession and trafficking punishable by severe penalties. The Runciman Report and Transform Drug Policy Foundation have made recommendations and proposals regarding the legal regulation of LSD and other psychedelics.
4 giorni fa · The largest reported overdose of naltrexone, which was 1,500 mg in a female patient and was equivalent to an entire bottle of medication (30 × 50 mg tablets), was uneventful. No deaths are known to have occurred with naltrexone overdose.
4 giorni fa · Drug overdose caused 1 in 370 deaths among seniors by 2021. From 2002 to 2021, the share of all-cause mortality attributable to drug overdose in older people increased 359%, going from 0.06% to 0.27% ( P <.001).
5 giorni fa · The reason opioid overdoses have reached historical highs comes from combining synthetic opioids with stimulants such as cocaine and methamphetamines, a lethal cocktail that is hard to reverse...
