Annunci · Cell penetrating peptides
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relativi a: cell penetrating peptidesSearch over 300,000 products and 500 service solutions for your research needs. Available today at SigmaAldrich.com
Unusual Amino Acids in Medicinal Chemistry. Amino acids are the building blocks of peptides and proteins
Revolutionize medical treatments with cell-penetrating peptides. Unlock the hidden potential of cell-penetrating peptides for targeted drug delivery.
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3 giorni fa · This review focuses specifically on cell-penetrating VDAC1-based peptides that were developed and used as a “decoy” to compete with VDAC1 for its VDAC1-interacting proteins. These peptides interfere with VDAC1 interactions, for example, with metabolism-associated proteins such as hexokinase (HK), or with anti-apoptotic proteins such as Bcl-2 and Bcl-xL.
7 ore fa · This involved sequential incorporation of targeted peptides (DGR or RGD), a NLS (KRRRR), a cell-penetrating peptide (RRRR), and an aggregation-induced emission molecule (PyTPE) followed by self-assembly with therapeutic genes through electrostatic interactions to form TNCP nanoparticles for highly effective nuclear-targeted therapy.
2 giorni fa · Regarding PMOs, one interesting approach consists of covalently attaching the PMO to a cationic peptide, such as cell-penetrating peptides (CPPs), known for their ability to improve cellular uptake. 26, 27, 28, 29 However, despite enhancing cell entry, CPP-conjugated PMOs (CPP-PMO), also known as peptide-morpholino oligomer ...
2 giorni fa · In general, the most common non-viral delivery methods employed are via physical electroporation of naked nucleic acids, or chemical methods involving complexation with lipids, cationic polymers, proteins, or cell penetrating peptides (CPPs) which package nucleic acids and facilitate intracellular delivery, summarised in Fig. 5.
1 giorno fa · Recent research on transportation methods identifies the conjugation of ASOs to cell-penetrating peptides as a strategy to increase uptake and an avenue for future inquiry . Although there are many hurdles involved in developing a possible ASO drug, achieving such a breakthrough could mean a magic bullet, theoretically able to silence any gene.
3 giorni fa · Dr Henriques combines expertise on cyclic disulfide-rich peptides, cell-penetrating peptides, antimicrobial peptides, and membrane biology. She has a strong background in biophysical methodologies to characterise peptide-membrane interactions.
3 giorni fa · Although there appeared to be a slight increase in cancer cell toxicity and caspase-3 activity with the complex formation and PD alone also exhibited ≈80% cell viability in B16F10 cells compared to NIH3T3 cells (Figure S7, Supporting Information), this trend was insufficiently pronounced to warrant a discussion of the anticancer activity of the peptides.
Annunci
relativi a: cell penetrating peptidesSearch over 300,000 products and 500 service solutions for your research needs. Available today at SigmaAldrich.com
Unusual Amino Acids in Medicinal Chemistry. Amino acids are the building blocks of peptides and proteins
Revolutionize medical treatments with cell-penetrating peptides. Unlock the hidden potential of cell-penetrating peptides for targeted drug delivery.
