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10 ore fa · The Price of Salt (later republished under the title Carol) is a 1952 romance novel by Patricia Highsmith, first published under the pseudonym "Claire Morgan."." Highsmith—known as a suspense writer based on her psychological thriller Strangers on a Train—used an alias as she did not want to be tagged as "a lesbian-book writer", [a] and she also used her own life references for characters ...
- Claire Morgan
- 1952
5 giorni fa · To enable ME neuromodulation at the single-cell level, MF must be converted into electrical polarization at the nanoscale. ME nanoparticles (MENPs) of CoFe 2 O 4 –BaTiO 3 were shown to generate ...
5 giorni fa · Messenger RNAs (mRNAs) have rapidly emerged as a pivotal class of biotherapeutics with great promise in the prevention and treatment of various diseases. As with other biotherapeutics, the sequence accuracy and integrity of mRNAs are critical quality attributes (CQAs), influencing the translation efficiency and protein expression fidelity of mRNAs. Due to the generation of short and repetitive ...
1 giorno fa · On 12 October 1984 the Provisional Irish Republican Army (IRA) attempted to assassinate members of the British government, including the prime minister, Margaret Thatcher, at the Grand Hotel in Brighton, England.
2 giorni fa · Using single-nucleus RNA sequencing (snRNA-seq), Migliorini et al. characterized the hematopoietic cells within the human fetal pancreatic microenvironment, uncovering distinct populations of tissue-resident macrophages. A co-culture system of hESC-derived organoids revealed that embryonic macrophages support endocrine cell differentiation, viability, and tissue engraftment, offering new ...
3 giorni fa · Ribonucleases (RNases) are ubiquitous in nature, being able to cleave a wide range of polyribonucleotides. While the presence of microbial and viral contamination in sterile manufacturing is highly studied and controlled, there are no standardized practices for evaluating RNase in the production facility. Since the COVID-19 pandemic, mRNA-LNP based vaccines have become part of routine large ...
2 giorni fa · Background/Objective: Current treatments for eosinophilic and mast cell disorders are often ineffective. One promising target to improve outcomes is sialic acid-binding immunoglobulin-like lectin-8 (Siglec-8). As limitations, there are few Siglec-8 monoclonal antibodies (mAbs) available to date, and Siglec-8-directed treatments have so far primarily focused on unconjugated mAbs, which may be ...
