Risultati di ricerca
5 giorni fa · In particular, DNA methylation appears critical for the maintenance of mono-allelic silencing in the context of genomic imprinting and X chromosome inactivation. [42] [43] In these cases, expressed and silent alleles differ by their methylation status, and loss of DNA methylation results in loss of imprinting and re-expression of Xist in somatic cells.
1 giorno fa · However, genetic contributions to sexual differentiation other than initiating testicular development have been increasingly documented. A classic example of genetic contribution to mammalian sexual differentiation is provided by X‑chromosome inactivation, which results in phenotypic mosaicism for traits influenced by X‑chromosome genes.
2 giorni fa · The inactivation of the X chromosome occurs randomly throughout the embryo, resulting in cells that are mosaic with respect to which chromosome is active. In some cases though, it appears that this switching off can occur in a non-random fashion.
4 giorni fa · The X chromosome is one of the two sex chromosomes that are involved in sex determination. Humans and most other mammals have two sex chromosomes (X and Y) that in combination determine the sex of an individual. Females have two X chromosomes in their cells, while males have one X and one Y.
1 giorno fa · 25 June 2024, 4.00 PM - 25 June 2024, 5.00 PM. Prof. Edith Heard (EMBL) OS6 Seminar Room, Oakfield House, Oakfield Grove, Bristol, BS8 2BN or Online. Part of the Mendel at 200 conference. Abstract: In female mammals, one of the two X chromosomes becomes inactivated during early development in order to achieve X-chromosome dosage compensation ...
3 giorni fa · X-linked, as related to genetics, refers to characteristics or traits that are influenced by genes on the X chromosome. Humans and most other mammals have two sex chromosomes, X and Y. Females have two X chromosomes in their cells, while males have one X and one Y.
2 giorni fa · Several X-linked genes escape from X chromosome inactivation (XCI), while differences in escape across cell types and tissues are still poorly characterized. Here, we developed scLinaX for directly quantifying relative gene expression from the inactivated X chromosome with droplet-based single-cell RNA-sequencing (scRNA-seq) data. The scLinaX and differentially expressed gene analyses with ...
