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Harvard called Wiley "one of the most influential biologists of his generation." In 1999, Wiley and another Harvard professor, Jack L. Strominger , won the Japan Prize for their discoveries of how the immune system protects humans from infections.
Don Wiley changed how we picture molecular organization at the cell surface. Indeed, he helped to create how we picture it. His two monumental contributions, the structures of influenza virus hemagglutinin in its various states and the structures of class I and class II MHC molecules in combination with peptides, superantigens, and T cell ...
31 gen 2002 · Wiley was a crystallographer: this is the ultimate molecular biology. One of the twentieth century's greatest discoveries, the structure of DNA, has its roots in X-ray crystallography.
- Hidde L. Ploegh
- ploegh@hms.harvard.edu
- 2002
Don Wiley was responsible for one of the major landmarks that has shaped modern molecular immunology. In 1987 he solved the three‐dimensional structure of an HLA class I molecule, occupied with peptide.
1 feb 2002 · With the tragic passing of Don Wiley, structural biology has lost one of its leading figures, renowned for his work in molecular immunology and virology.
- Jack L. Strominger
- 2002
As a graduate student, Don set an ambitious goal for himself—to provide a structural explanation for the mechanism of allosteric regulation in aspartate transcarbamylase, resulting in a 5.5 Å structure at a time when a project of this magnitude was virtually inconceivable.
Don Wiley’s work as a structural biologist was by no means confined to HLA molecules. He solved the structure of sev-eral viral proteins, including influenza haemagglutinin in 1977. This furnished insights into viral evasion, and how the im-mune system attempts to keep the upper hand.
