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Analyze your protein sequence for Pfam matches. View Pfam annotation and alignments. See groups of related entries. Look at the domain organisation of a protein sequence. Find the domains on a PDB structure. Query Pfam by keywords. GO.
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The Pfam database is a large collection of protein families, each represented by multiple sequence alignments and hidden Markov models (HMMs). More... Proteins are generally composed of one or more functional regions, commonly termed domains .
InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites. We combine protein signatures from a number of member databases into a single searchable resource, capitalising on their individual strengths to produce a powerful integrated database and diagnostic tool.
Pfam is a database of protein families that includes their annotations and multiple sequence alignments generated using hidden Markov models. Last version of Pfam, 36.0, was released in September 2023 and contains 20,795 families. It is currently provided through InterPro database.
1 gen 2021 · Pfam is a database of protein families and domains that is widely used to analyse novel genomes, metagenomes and to guide experimental work on particular proteins and systems (1,2). Each Pfam family has a seed alignment that contains a representative set of sequences for the entry.
- Jaina Mistry, Sara Chuguransky, Lowri Williams, Matloob Qureshi, Gustavo A Salazar, Erik L L Sonnham...
- 10.1093/nar/gkaa913
- 2021
- 2021/01/01
8 gen 2021 · The Pfam database is a widely used resource for classifying protein sequences into families and domains. Since Pfam was last described in this journal, over 350 new families have been added in Pfam 33.1 and numerous improvements have been made to existing entries.
Pfam è un database di famiglie di proteine che include le loro annotazioni e gli allineamenti di sequenze multiple generati usando i modelli di Markov nascosti.