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Roberto NEGRO of Harvard Medical School, MA (HMS) | Contact Roberto NEGRO
18 set 2020 · Abstract. Inflammasomes are supramolecular complexes that play key roles in immune surveillance. This is accomplished by the activation of inflammatory caspases, which leads to the proteolytic maturation of interleukin 1β (IL-1β) and pyroptosis.
- Venkat Giri Magupalli, Venkat Giri Magupalli, Roberto Negro, Roberto Negro, Yuzi Tian, Yuzi Tian, Ar...
- 2020
Gennaio 2013 - Marzo 2020: Post-dottorato presso l’Harvard Medical School, Dipartimento di Chimica Biologica e Farmacologia Molecolare - Immune Disease Institute presso il Boston Children’s Hospital (Massachusetts, USA) sotto la supervisione della Prof.ssa Hao Wu.
Ph.D., Harvard Chemical Biology Graduate School of Arts and Sciences. Post-Doc Fellow, Harvard Medical School
Roberto NEGRO | Cited by 7,319 | | Read 122 publications | Contact Roberto NEGRO
5 feb 2019 · NLRP6 is a sensor protein in the nucleotide-binding domain (NBD) and leucine-rich repeat (LRR)-containing (NLR) inflammasome family that has been shown to play multiple roles in regulating inflammation and host defenses.
11 nov 2021 · NLRP6 is important in host defense by inducing functional outcomes including inflammasome activation and interferon production. Here, we show that NLRP6 undergoes liquid-liquid phase separation (LLPS) upon interaction with double-stranded RNA (dsRNA) in vitro and in cells, and an intrinsically disor ….