Risultati di ricerca
Roberto NEGRO of Harvard Medical School, MA (HMS) | Contact Roberto NEGRO
18 set 2020 · Abstract. Inflammasomes are supramolecular complexes that play key roles in immune surveillance. This is accomplished by the activation of inflammatory caspases, which leads to the proteolytic maturation of interleukin 1β (IL-1β) and pyroptosis.
- Venkat Giri Magupalli, Venkat Giri Magupalli, Roberto Negro, Roberto Negro, Yuzi Tian, Yuzi Tian, Ar...
- 2020
Ph.D., Harvard Chemical Biology Graduate School of Arts and Sciences. Post-Doc Fellow, Harvard Medical School
5 feb 2019 · NLRP6 is a sensor protein in the nucleotide-binding domain (NBD) and leucine-rich repeat (LRR)-containing (NLR) inflammasome family that has been shown to play multiple roles in regulating inflammation and host defenses.
- Chen Shen, Chen Shen, Alvin Lu, Alvin Lu, Wen Jun Xie, Jianbin Ruan, Jianbin Ruan, Roberto Negro, Ro...
- 2019
Roberto NEGRO | Cited by 7,319 | | Read 122 publications | Contact Roberto NEGRO
Roberto NEGRO, Senior Researcher | Cited by 507 | of IRCCS Saverio de Bellis, Bari (IRCCS de Bellis) | Read 15 publications | Contact Roberto NEGRO.
Recent studies suggest that TRPM2 is a calcium-permeable cation channel mediating ROS-dependent NLRP3 activation. Here, we review the role of TRPM2 in NLRP3 inflammasome activation and provide an update on new functional and structural discoveries.