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1. www.nature.com › articles › s41467/022/31993-yMulti-step screening of DNA/lipid nanoparticles and co ... -...

   www.nature.com › articles › s41467/022/31993-y

   25 lug 2022 · Lipid nanoparticles hold great potential as an effective non-viral vector for nucleic acid-based gene therapy. Plasmid DNA delivery can result in extended transgene expression compared to mRNA...

2. www.ncbi.nlm.nih.gov › pmc › articlesEfficient Delivery of DNA Using Lipid Nanoparticles - PMC

   www.ncbi.nlm.nih.gov › pmc › articles

   15 ago 2022 · To overcome these limitations, in this work, we use a microfluidic platform to generate DNA-loaded lipid nanoparticles (LNPs) which are then characterized by a combination of dynamic light scattering (DLS), synchrotron small-angle X-ray scattering (SAXS), and transmission electron microscopy (TEM).

   • DOI: 10.3390/pharmaceutics14081698
   • Pubblicato: 2022/08

   • Publication: Pharmaceutics. 2022 Aug; 14(8): 1698.

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4. www.nature.com › articles › s41598/020/65059-0Lipid Nanoparticle Formulation Increases Efficiency of DNA ... -...

   www.nature.com › articles › s41598/020/65059-0

   29 mag 2020 · This work provides a proof-of-concept that LNP formulation of DNA vaccines can be used to produce more potent active vaccines, passive countermeasures (e.g., Tc bovine), and as a means to...

   • Autore: Eric M. Mucker, Priya P. Karmali, Jerel Vega, Steven A. Kwilas, Hua Wu, Matthew Joselyn, John Ballan...

   • Publish Year: 2020

5. pubmed.ncbi.nlm.nih.gov › 35475455In vivo delivery of plasmid DNA by lipid nanoparticles: the...

   pubmed.ncbi.nlm.nih.gov › 35475455

   31 mag 2022 · Here we report the first investigation into pDNA transfection efficiency in different mouse organs after intramuscular and intravenous administration of lipid nanoparticles (LNPs) where DLin-MC3-DMA, DLin-KC2-DMA or DODAP are used as the ionizable cationic lipid component of the LNP.

6. www.sciencedirect.com › science › articleLipid nanoparticles for nucleic acid delivery: Current...

   www.sciencedirect.com › science › article

   1 gen 2020 · Lipid Nanoparticles (LNP) have been extensively investigated for the delivery of nucleic acid (NA) drugs, culminating with the approval of Onpattro for treatment of Amyloidosis in the US and EU in 2018.

   • Autore: Eleni Samaridou, James Heyes, Peter Lutwyche

   • Publish Year: 2020

7. pubmed.ncbi.nlm.nih.gov › 34286581Lipid Nanoparticle Spherical Nucleic Acids for Intracellular DNA...

   pubmed.ncbi.nlm.nih.gov › 34286581

   11 ago 2021 · Lipid nanoparticle SNAs (LNP-SNAs) have been synthesized for the delivery of DNA and RNA to targets in the cytoplasm of cells. Both the composition of the LNP core and surface-presented DNA sequences contribute to LNP-SNA activity.

8. www.nature.com › articles › s12276/023/01086-xImmunogenicity of lipid nanoparticles and its impact on the ... -...

   www.nature.com › articles › s12276/023/01086-x

   2 ott 2023 · The LNP industry based on gene therapy and editing has high potential for development, and ongoing clinical trials suggest that DNA and mRNA vaccines will continue to dominate treatment...