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  1. Sir Augustus Frederick d'Este, KCH (13 January 1794 – 28 December 1848) was a relative of the British royal family and the earliest recorded person for whom a definite diagnosis of multiple sclerosis can be made.

  2. Sir Augustus Frederick D’Esté (1794–1848) was an illegitimate royal child, a bachelor, an active member of the Aborigines Protection Society, and the earliest known person diagnosed with multiple sclerosis.

  3. 17 ott 2009 · The personal diary of Sir Augustus d’Esté, born 1794 grandson of King George III of England, reveals a medical history strongly suggesting that Augustus suffered from multiple sclerosis (MS). It could well be the first record of a person having this disease.

    • Anne Marie Landtblom, Patrik Fazio, Sten Fredrikson, Enrico Granieri
    • 2010
  4. È singolare che la più antica descrizione sui sintomi e sul decorso clinico della sclerosi multipla, detta anche sclerosi a placche, si debba a Sir Augustus D'Este, nipote del Re Giorgio III d'Inghilterra che tra il 1822 e il 1848 ha scritto in un diario e in un almanacco una cronaca personale della malattia che lo ha colpito.

  5. Abstract. The personal diary of Sir Augustus d’Este ́, born 1794 grandson of King George III of England, reveals a medical history strongly suggesting that Augustus suffered from multiple sclerosis (MS). It could well be the first record of a person having this disease.

    • Anne Marie Landtblom, Patrik Fazio, Sten Fredrikson, Enrico Granieri
    • 2010
  6. It is a singular fact that the earliest account of the symptoms and clinical history of multiple sclerosis was written by Sir Augustus d'Este, a grandson of King George III of England, who kept a personal diary and record of his disease between 1822 and 1848.

  7. 4 feb 2021 · It survives in the diaries (1822-48) and almanac of Sir Augustus D’Este, the Harrovian grandson of King George III. 1,2 In December 1822, when he was twenty-eight years old, Augustus suffered impaired vision in both eyes that recovered—probably bilateral optic neuritis.