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4 dic 2019 · Pharmacology of local anaesthetics. Local anaesthetic drugs are water-soluble salts of lipid-soluble alkaloids. The structure of local anaesthetics consists of three components: a lipophilic aromatic group, an intermediary link and a hydrophilic amine group (Fig. 2).
- A. Taylor, G. McLeod
- 10.1016/j.bjae.2019.10.002
- 2020
- BJA Educ. 2020 Feb; 20(2): 34-41.
Learning objectives. By reading this article, you should be able to: Describe the basic structure of local anaesthetic agents. Illustrate the relationships between the structure, function and toxicity of local anaesthetic agents. Identify the pharmacological profiles of commonly used local anaesthetics. Introduction.
Introduction. Local anaesthetic drugs are used widely for the provision of anaesthesia and analgesia both intra- and post-operatively. Understanding the pharmacology of these agents as a group, as well as the differences between specific drugs, enables the anaesthetist to use them safely to maximum effect.
15 lug 2020 · Pharmacokinetics and Pharmacodynamics of Local Anesthetics. July 2020. DOI: 10.5772/intechopen.91700. License. CC BY 3.0. In book: Topics in Local Anesthetics [Working Title] Authors:...
The two most commonly used are EMLA (eutectic mixture of local anaesthetic; 2.5% lidocaine and 2.5% prilocaine) and Ametop (4% tetracaine). These should be applied around 1 hour prior to the procedure and provide surface anaesthesia for up to 2 hours and 4 hours, respectively.
14 dic 2021 · Pharmacological and clinical implications of local anaesthetic mixtures: a narrative review. December 2021. Anaesthesia 77 (3) DOI: 10.1111/anae.15641. Authors: Claire Nestor. Tallaght...
1 feb 2020 · Local anaesthetics (LA) are weak bases consisting of a lipophilic aromatic ring linked to a hydrophilic tertiary amine by either an ester or amide bond. It is this chemical link that enables classification of the LA. They exist in solution as an equilibrium of ionized and unionized forms.
