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Malondialdehyde belong to the class of β-dicarbonyls. A colorless liquid, malondialdehyde is a highly reactive compound that occurs as the enol. It is a physiological metabolite, and a marker for oxidative stress.
- 108 °C (226 °F; 381 K)
- 72 °C (162 °F; 345 K)
- C₃H₄O₂
- 72.063 g·mol−1
27 giu 2019 · Since the bulk of MDA derives from the lipid peroxidation of PUFAs in plant membranes in response to oxidative stress (via ROS and/or lipoxygenase), MDA content is widely used as an indicator of damage in plant membranes. This holds true if MDA levels remain high, irreparably modifying proteins and nucleic acids.
- Melanie Morales, Sergi Munné-Bosch
- 10.1104/pp.19.00405
- 2019
- Plant Physiol. 2019 Jul; 180(3): 1246-1250.
27 giu 2019 · The measurement of malondialdehyde (MDA) content has long been used as a lipid peroxidation marker in studies related to oxidative stress and redox signaling, particularly in those studies focused on plant responses to abiotic and biotic stresses.
- Melanie Morales, Sergi Munné-Bosch
- 2019
26 lug 2015 · Malondialdehyde (MDA) is the most frequently used biomarker of oxidative stress in many health problems such as cancer, psychiatry, chronic obstructive pulmonary disease, asthma, or cardiovascular diseases. This perspective study aimed to collect some evidence for low reliability of the MDA as a biomarker of oxidative stress.
- Maryam Khoubnasabjafari, Khalil Ansarin, Abolghasem Jouyban
- 10.15171/bi.2015.20
- 2015
- Bioimpacts. 2015; 5(3): 123-127.
Malondialdehyde (MDA), an end product of lipid peroxidation, can bind to DNA and form adducts as it does with other endogenous compounds. 172 These adducts were found to be highly mutagenic in E. coli 173 and are repaired by nucleotide excision repair.
9 ago 2023 · Malondialdehyde (MDA) is a compound that is derived from the peroxidation of polyunsaturated fatty acids. It has been used as a biomarker to measure oxidative stress in various biological samples in patients who are affected by a wide range of diseases.
29 mar 2022 · It is defined as an imbalance between the production and elimination of reactive oxygen species (ROS). ROS can oxidize proteins, lipids, and DNA, and some of these oxidized products are excreted in urine, such as malondialdehyde (MDA), which is considered a biomarker for oxidative damage of lipids.
