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Pfam also generates higher-level groupings of related entries, known as clans. A clan is a collection of Pfam entries which are related by similarity of sequence, structure or profile-HMM. The data presented for each entry is based on the UniProt Reference Proteomes but information on individual UniProtKB sequences can still be found by entering the protein accession.
InterPro. Loading the InterPro website, please wait. InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites. We combine protein signatures from a number of member databases into a single searchable resource, capitalising on their individual strengths to produce a powerful ...
You can find data in Pfam in various ways... Analyze your protein sequence for Pfam matches. View Pfam family annotation and alignments. See groups of related families. Look at the domain organisation of a protein sequence. Find the domains on a PDB structure. Query Pfam by keywords.
Pfam è un database di famiglie di proteine che include le loro annotazioni e gli allineamenti di sequenze multiple generati usando i modelli di Markov nascosti.
1 gen 2021 · Pfam is a database of protein families and domains that is widely used to analyse novel genomes, metagenomes and to guide experimental work on particular proteins and systems (1,2). Each Pfam family has a seed alignment that contains a representative set of sequences for the entry.
- Jaina Mistry, Sara Chuguransky, Lowri Williams, Matloob Qureshi, Gustavo A Salazar, Erik L L Sonnham...
- 10.1093/nar/gkaa913
- 2021
- 2021/01/01
Pfam is a database of conserved evolutionary units. It can be used to explore domain(s) and other functional regions in a protein and give insight into the function of that protein.
8 gen 2021 · Abstract. The Pfam database is a widely used resource for classifying protein sequences into families and domains. Since Pfam was last described in this journal, over 350 new families have been added in Pfam 33.1 and numerous improvements have been made to existing entries.
